Adipocyte apoptosis

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August undefined, 2024

WebJun 1, 2016 · TNF-α is a pro-inflammatory cytokine that is increased in obese WAT and induces adipocyte apoptosis in more than 50% of the cells after 24 h of incubation (23, 29). We note that the mechanism of adipocyte death in vivo is controversial and other forms of cell death, such as pyroptosis, may play a role in addition to apoptosis (12, 30, 31 ... WebNational Center for Biotechnology Information

BMPR2 promotes fatty acid oxidation and protects white adipocytes …

WebJan 31, 2024 · Adipocyte apoptosis was measured by FITC-labeled annexin V/PI staining and TUNEL staining. An Annexin V-FITC and TUNEL apoptosis assay kit (Vazyme, Nanjing, China) was used according to the manufacturer’s protocol. The cells were then observed using a Nikon TE2000-U microscope, and the data were analyzed by using … WebNov 1, 2001 · Adipocyte apoptosis is an important regulator of adipocyte number in fat depots. We have previously shown that an inhibition of protein synthesis sensitizes human adipocytes for apoptosis. In vivo ... slow cooker curry sauce

Adipocyte death triggers a pro-inflammatory response …

WebApr 29, 2024 · Adipocyte cell death is pathologically involved in both obesity and lipodystrophy. Inflammation and pro-inflammatory cytokines are generally regarded as inducers for adipocyte apoptosis, but... WebJan 6, 2012 · Apoptosis is a normal phenomenon of cell death for the purpose of maintaining homeostasis. Induction of apoptosis is a reasonable way to remove … WebJan 29, 2010 · Adipocyte death has been reported in both obese humans and rodents. However, its role in metabolic disorders, including insulin resistance, hepatic steatosis, … slow cooker curry lamb

Adipocyte Apoptosis, a Link between Obesity, Insulin …

Human Adipocyte Apoptosis Immediately Following High

WebApr 13, 2024 · White adipocytes store and release energy according to systemic demand, whereas brown and beige adipocytes burn energy to produce heat. Brown and beige adipocytes are characterized by a high density of mitochondria that contain uncoupling protein 1 (UCP1) in their inner membrane. WebJan 6, 2012 · Adipocytes could be removed through apoptotic mechanisms in some pathological conditions, such as in patients with tumor cachexia and HIV-infected … slow cooker curry recipe ukWebApr 11, 2024 · Isolation and identification of human ADSCs. A The isolated ADSCs exhibited typical fibroblast-like morphology. Bar: 100 μm. B Induction of ADSCs into adipocytes, osteoblast, and chondrocytes with adipogenic, osteogenic and chondrogenic medium, respectively. Bar:100 μm. C ADSCs showed strong positive (more than 95%) expression … slow cooker curry recipes indian

"WebApr 14, 2013 · Apoptosis and autophagy are upregulated in human visceral adipose tissue of patients with type 2 diabetes. Ghrelin plays a role in the control of apoptosis and … " - Adipocyte apoptosis

Adipocyte apoptosis

WebMay 29, 2024 · In obese C57BL/6 mice, oral administration of T-AG17 (0.175 mg/kg for 2 weeks) lead to decreased fat accumulation and WAT hypertrophy. Further, T-AG17 induced adipocyte apoptosis by activating caspase-3. In the hepatocytes of obese mice, T-AG17 promoted an increase in the size of lipid inclusions, which was accompanied by glycogen … WebApr 14, 2013 · Apoptosis is an important homoeostatic mechanism controlling adipocytes number, and excessive adipocyte apoptosis appears to be of some concern related to detrimental metabolic effects of fat...

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WebJul 1, 2001 · Research on adipocyte apoptosis has been limited owing to the remarkable ability of adipocytes to resist apoptosis. However, according to in vivo and in vitro evidence, the loss of mature fat...

WebMar 2, 2024 · TNFα-induced apoptosis and gene expression are critical in human adipocyte apoptosis. An in vitro study demonstrated 3T3-L1 adipocyte apoptosis induced by TNF-α was essentially regulated via controlling NF-κB activation, by targeting the TANK gene 18. Adiponectin is an important adipocyte-secreted adipokine. WebAdipocyte differentiation, or adipogenesis, is a regulated process. Alterations in fat mass result from changes in adipocyte size, number, or both. A change in adipocyte number …

WebJul 18, 2011 · Concomitantly, adipocytes undergo programmed cell death with the loss of the adipocyte-specific lipid droplet protein perilipin, and the dead/dying adipocytes are surrounded by macrophages that are organized into crown-like structures. WebJul 8, 2024 · Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20247 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was...

WebJan 6, 2012 · Apoptosis is a normal phenomenon of cell death for the purpose of maintaining homeostasis. Induction of apoptosis is a reasonable way to remove adipocytes in obese patients. It is reported that several adipokines and natural products play roles in induction of adipocyte apoptosis.

WebThese data strongly suggest that adipocyte apoptosis is a key initial event that contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis … slow cooker curry sausagesWebJan 31, 2024 · Collectively, our findings establish ColXV as a basement membrane collagen with homology to ColXVIII, indicating that it is one of the positive regulators for inducing ECM remodeling and further promoting adipocyte apoptosis. Keywords: Collagen XV; adipocytes; apoptosis; extracellular matrix remodeling; fibroblast growth factor 2. slow cooker curry recipes nzWebApoptosis or programmed cell death is a central mechanism for maintaining homeostasis. This natural process of cell removal enables the body to rid itself of selected cells safely and effectively. 1 The potential benefits of induced apoptosis, specifically to the abdominal region, extends beyond aesthetics as it may help reduce metabolic complications in … slow cooker currysWebOct 12, 2024 · Adipose tissue plays a crucial role in the regulation of metabolic homeostasis through cross talk with other metabolic tissues. Adipose tissue is expanded by two processes, formation of new adipocytes (hyperplasia) and enlargement of existing adipocytes (hypertrophy) ( 1 ). slow cooker curry using jarWebOct 27, 1997 · It is shown that human adipocytes undergo apoptosis following growth factor deprivation or mild heat injury in vitro, thus demonstrating a cellular mechanism by which normal adipocyte loss could occur in vivo. 96 Tumor necrosis factor-alpha and its second messenger, ceramide, stimulate apoptosis in cultured ovarian follicles. slow cooker curry slimming worldWebJun 1, 2015 · At follow-up, treated adipocytes demonstrated nuclear and shape changes with consequent fat reduction. Adipocytes were found to be flattened/shrunken and of smaller size (-33.5% at 1 week;... slow cooker curry sausages recipe easyWebApr 9, 2024 · Apoptosis Assays. BMSCs were seeded at the density of 10 6 cells per plates, and treated with osteogenic induction medium containing TAA, ORI or TAA + ORI for 14 days. Then the cells were collected and stained with Annexin V-FITC/PI apoptosis kit (Multi sciences, AP101). ... BMSCs tend to differentiate into adipocytes rather than … slow cooker curry soup