Cisplatin uptake rates

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August undefined, 2024

WebMar 26, 2024 · Collectively, these lines of evidence documented that the three cisplatin-resistant cancer cells showed increased intracellular hypoxia. To unveil the underlying mechanism of the increased intracellular hypoxia, we tested the glucose uptake rate of both BEL7404 and BEL7404DDP cancer cells. WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP.

Long After Chemotherapy, Cisplatin and Hearing Loss Remain

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … WebOct 7, 2002 · We have also found that cisplatin reduced uptake of 64 Cu into wild-type cells; when treated for 2 h with 1 mM cisplatin, the level of 64 Cu uptake was 16% of that of … chisasibi elementary school

Cisplatin-Membrane Interactions and Their Influence on Platinum ...

WebDec 30, 2024 · To maintain resistance in A2780cisR cells, cisplatin (1 μ M) was added to the medium every two passages. Continuous treatments (CT) were carried out at 37°C in a humidified chamber with 5% CO 2. Cisplatin was dissolved in a 0.9% w/v NaCl aqueous solution and brought to pH = 3 with HCl (final stock concentration 1 mM). WebJun 23, 2024 · In situations where cisplatin uptake is hindered by encapsulation, it may be beneficial to use ZIFs with larger kno pores that can display a similar rate of retention … WebFeb 14, 2024 · Cisplatin (60 mg/m2× 2 days per cycle) was administered concurrently with pantoprazole (intravenous [IV], 1.6 mg/kg over 4 hours) on cycles 1 and 2 or cycles 3 and 4 in 12 patients with osteosarcoma (OS) with a median (range) age of 12.8 (5.6–19) years. Audiograms, urinary AKI biomarkers, and serum cystatin C were monitored during each … chi sash lyrics

Long After Chemotherapy, Cisplatin and Hearing Loss Remain

Drug uptake-based chemoresistance in breast cancer treatment

WebFeb 24, 2024 · The 5-year survival rate was 49% for surgery with or without radiation therapy versus 52% (P = .2) for radiation therapy with or without neck dissection. The rate of severe complications was 32% for the surgery group versus 3.8% for the radiation therapy group (P < .001). WebFeb 28, 2024 · Cisplatin is a highly polar species, and its cellular accumulation generally occurs at a slower rate compared with that of other small-molecule anticancer drugs. Apart from passive diffusion, other non-saturable systems, such as fluid-phase endocytosis, may be involved in platinum drug uptake, and evidence for some active or facilitated ... chisasibi band councilWebApr 17, 2024 · Reported rates of cisplatin ototoxicity vary widely, though it is believed that at least half of all patients treated with cisplatin will suffer hearing loss. As cisplatin is widely used, this rate of ototoxicity translates to hundreds of thousands of patients affected each year in the United States alone. chemo, cancer, hearing loss chisasibi health center

"WebSep 6, 2012 · Comparing the long-term effects of cisplatin administration at low (20 mg cisplatin/m 2) and high (40 mg/m 2) doses after 4 cycles of daily treatment for 5 days, a small but significant decrease in 51 Cr-EDTA clearance was … " - Cisplatin uptake rates

Cisplatin uptake rates

WebOct 5, 2014 · The addition of cisplatin to cyclophosphamide and doxorubicin (CAP) has been recently associated with overall response rates of 57% to 100% and complete … WebBoth solvated and non-solvated simulations show that cisplatin release rates can be controlled by either ... energies and small pore window diameters will hinder cisplatin …

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WebThe uptake of cisplatin in renal tubular cells is high, leading to cisplatin accumulation and tubular cell injury and death, culminating in acute renal … The copper transporter Ctr1 contributes to cisplatin uptake by renal tubular cells during cisplatin nephrotoxicity Am J Physiol Renal Physiol. WebCisplatin Prices, Coupons and Patient Assistance Programs. Cisplatin is a member of the alkylating agents drug class and is commonly used for Anal Cancer, Bladder Cancer, …

WebJan 17, 2024 · NMIBC is of low grade, accounts for approximately 70% of UBC occurrences, and demonstrates a 5-year survival rate of 90%. Even though they are not possibly life-threatening, they have a proclivity for recurrence, ... CTR1 knockdown has been shown to lower cisplatin uptake by over 80% in both yeast and mouse embryonic fibroblasts . Webglomerular ﬁltration rate, higher serum creatinine, and reduced serum magnesium and potassium levels.4,19,20 On the other hand, the long-term effects of cisplatin on renal ... the cisplatin uptake is due to passive diffusion through the plasma membrane, and the remaining half is mediated by an unknown transporter.22 In 2002, ...

WebJan 11, 2024 · In this regard, evidence suggests that the major mechanisms involved in cisplatin uptake are through passive diffusion and through facilitated transporters in particular organic cation transporters, such as, copper transporters (Ctr1) (Ishida et al., 2002). Transmembrane passive diffusion is a process that depends on both the size and ... WebNational Center for Biotechnology Information

WebMaterials and methods: Cisplatin (60 mg/m 2 × 2 days per cycle) was administered concurrently with pantoprazole (intravenous [IV], 1.6 mg/kg over 4 hours) on cycles 1 and 2 or cycles 3 and 4 in 12 patients with osteosarcoma (OS) …

WebJul 31, 2014 · A, degree of nephrotoxicity based on histology scores observed in kidneys isolated from wild-type (WT; n = 30), and Oct1/2 −/− (mice n = 18) 72 hours after administration of cisplatin. Toxicity scores are based on percentage of damaged tubules: 0 (<10%, absent), 1 (11%–25%, minimal), 2 (26%–50%, mild), 3 (51%–75%, moderate), … graphite deckingWebSep 18, 2024 · NCBI Bookshelf chisasibi driving schoolWebJan 11, 2024 · Studies in cells also showed that cisplatin can be taken up by passive diffusion mechanisms since its accumulation by concentration gradient up to its saturation point was not the rate limiting factor ( … chisasibi business service centerWebOct 3, 2014 · There, it can be seen that activated cisplatin causes a significant (about 40–50%) reduction in Rb + uptake, indicating a cisplatin-induced inhibition of the Na … graphite december 2022WebOct 3, 2014 · One possible mechanism by which resistance is reported to develop is a reduction in drug uptake across the cell membrane. While the passive uptake of cisplatin has long been cited as an... chisasibi cree constructionWebTwo major issues which hamper the use of the anticancer drug cisplatin are the development of cancer cell resistance and its nephrotoxicity. One possible mechanism … chisasibi cree nationWebApr 7, 2024 · The rate of dose-limiting toxicities, especially grade 2 or greater hematologic toxicity, increases with the number of cycles of cisplatin chemotherapy [10, 11]. More cycles of cisplatin reduce the patient's ability to tolerate CCRT and the patient’s quality of life; hence, CCRT completed beyond 8 weeks affects the survival of patients [ 12 ... chisasibi high school